Supercritical solvent impregnation of ophthalmic drugs on chitosan derivatives

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Supercritical solvent impregnation of ophthalmic drugs on chitosan derivatives

Mara E.M. Braga a,∗, Maria T. Vaz Pato a, Hélio S.R. Costa Silva b, Elisabeth I. Ferreira b, Maria H. Gil a, Catarina M.M. Duarte c, Hermı́nio C. de Sousa a a Department of Chemical Engineering, University of Coimbra, Pólo II, Rua Sı́lvio Lima, 3030-790 Coimbra, Portugal b Faculdade de Ciências Farmacêuticas, USP, Av. Professor Lineu Prestes 580, Bloco 13, 05508-900 São Paulo, SP, Brazil c Nutrac...

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A supercritical fluid can be used in substitution of the original organic solvent for the preparation of pharmaceutical forms. The steps involved in the preparation are essentially similar to those of the traditional preparation but in this case the final purification is not required. The interest in the supercritical fluid impregnation of polymeric materials stems from the opportunity to utili...

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Supercritical Drug Impregnation onto Intraocular Lenses

Supercritical impregnation is an attractive “clean” alternative to conventional soaking into liquid process, using generally organic solvents. Impregnation process can be used for the development of controlled delivery systems that can be applied in pharmaceutical and medical fields. This work focuses on the preparation of controlled drug delivery systems for ophthalmic applications through sup...

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ژورنال

عنوان ژورنال: The Journal of Supercritical Fluids

سال: 2008

ISSN: 0896-8446

DOI: 10.1016/j.supflu.2007.10.002